Leicestershire Health Community
Medicines Formulary
 
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6 Endocrine system
06-02-02 Antithyroid drugs

Carbimazole
First Choice
Typical starting doses: Free T4 >30 - Carbimazole 40mg once daily (2x20mg tablets) for 1 month then reduced to 20mg once daily with repeat thyroid function tests at 6 weeks. Free T4 <30 - Carbimazole 20mg once daily.
Link  MHRA Advice: Carbimazole: increased risk of congenital malformations; strengthened advice on contraception
Link  MHRA Advice: Carbimazole: risk of acute pancreatitis
 

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Propylthiouracil
Second Choice

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Iodine and Iodide Aqueous Iodine Oral Solution
Restricted
Preparation for thyroidectomy. Start about 2 weeks preoperatively

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Propranolol IV
Restricted
Can be given I.V in doses of 1mg up to 5mg in thyrotoxic crisis. Hydrocortisone and aqueous iodine should also be given (seek specialist advice)
See also section 2.4

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