Leicestershire Health Community
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6 Endocrine system
06-01-02-02 Biguanides

Metformin Hydrochloride
First Choice
Drug of choice for obese/ overweight patients
Gastro intestinal adverse events can be reduced by a gradual dose titration, e.g. 500mg od for 7 days, 500mg bd for 7 days, 1000mg am 500mg pm for 7 days etc. to maximal tolerated dose.

Green View adult BNF  View SPC online
Metformin Hydrochloride MR
Restricted
For patients who are unable to tolerate GI side effects despite dose titration. A 750mg tablet and a 1000mg are now available and are less costly than using multiples of the 500mg tablet.

Restricted Drug Green View adult BNF  View SPC online